Angiopoietin-1 induces survival and proliferation of hair follicle dermal papilla cells through integrin α5β1 signaling.

ABSTRACT:

Background

Androgenetic alopecia is a common form of hair loss primarily mediated by dihydrotestosterone (DHT), which induces apoptosis and inhibits proliferation in dermal papilla cells (DPCs). Current treatments, such as minoxidil and finasteride, often show limited efficacy and can cause adverse effects, underscoring the need for safer and more targeted therapies.

Methods

This study investigated the protective and proliferative effects of angiopoietin-1 (Ang1) on human follicle dermal papilla cells (HFDPCs) under DHT-induced stress. Apoptosis and proliferation were assessed using flow cytometry and BrdU assays. Western blotting was used to examine intracellular signaling pathways. The expression and functional relevance of Tie and integrin receptors were evaluated using g

SUBMITTER: Yun JH 

PROVIDER: S-EPMC12504495 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature