Immunocompetent C57BL/6 syngeneic mouse ovarian cancer models with defined genetic alterations.

ABSTRACT: Ovarian cancer remains one of the deadliest gynecologic cancers globally, with limited progress in early detection and treatment. Syngeneic mouse ovarian cancer cell lines, derived from immunocompetent mice, have become essential tools for studying ovarian cancer biology and assessing novel therapies. With the rise of immunotherapies such as immune checkpoint inhibitors and cancer vaccines, these syngeneic models are critical for preclinical studies within the context of an intact immune system. The availability of diverse syngeneic ovarian cancer models ensures that research captures the full spectrum of human ovarian cancer variability, including variations in genetic mutations, signaling pathways, tumor antigenicity, and molecular subtypes. Here, we report the development and characteri

SUBMITTER: Agadjanian H 

PROVIDER: S-EPMC12504517 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature