Subjective cognitive decline in individuals with isolated REM sleep behavior disorder.

ABSTRACT: Subjective cognitive decline (SCD) may constitute an early marker of mild cognitive impairment (MCI) in individuals with isolated REM sleep behavior disorder (iRBD). In this cross-sectional study, 80 individuals with iRBD were classified into iRBD with MCI (RBD.MCI), with SCD (RBD.SCD+), and without both (RBD.SCD-) based on neuropsychological testing and the Multi-SubCoDE questionnaire. The prevalence of SCD in iRBD was 36.3%, with predominance of the amnestic multi-domain SCD profile. RBD.SCD+ reported more severe depressive symptoms than RBD.SCD- and showed lower cognitive performance than RBD.SCD- in global cognition and attention & working memory. Magnetic resonance imaging analyses revealed lower grey matter volume in the left superior frontal gyrus for RBD.SCD+ than RBD.SCD-, which w

SUBMITTER: Ophey A 

PROVIDER: S-EPMC12504634 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature