A One Health framework for global and local stewardship across the antimicrobial lifecycle.

ABSTRACT: Antimicrobial resistance (AMR) is a One Health challenge, affecting human and animal health, plants and the environment. It has significant impacts on population health, food security and economies of all countries. AMR is a complex problem that requires broad One Health stewardship from local to global levels, encompassing infection prevention together with stewardship across the six stages of the antimicrobial lifecycle, i.e., (1) research and development, (2) production, (3) registration evaluation and market authorization, (4) selection, procurement and supply, (5) appropriate and prudent use and (6) disposal, as outlined by the World Health Organization (WHO), the Food and Agriculture Organization (FAO), and the World Organization for Animal Health (WOAH). This requires the stewardshi

SUBMITTER: Altevogt BM 

PROVIDER: S-EPMC12504729 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature