KDM4B modulates ERα signaling pathway to participate in vascular smooth muscle cell calcification.

ABSTRACT: Vascular calcification (VC) is recognized as an independent predictor of cardiovascular events. Although estrogen replacement is a controversial treatment due to its potential carcinogenic effects, it was considered a protective treatment against VC in postmenopausal women. Estrogen receptor α (ERα) co-regulators were considered as potential therapeutic targets for ERα-related cancers. However, ERα activity and the biological function modulation of ERα co-regulators in VC remain elusive. Histone lysine demethylase 4B (KDM4B) was identified to be highly expressed in human and mouse aortic smooth muscle (ASMC) cells treated with β-phosphoglycerol and in mice overloaded with VitD3 during calcification, as evidenced by western blotting and immunofluorescence staining. Co-immunoprecipitation (C

SUBMITTER: Liu F 

PROVIDER: S-EPMC12504744 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature