Causal Relationship Between Brain Functional Networks and Sleep Disorders: A Mendelian Randomization Study.

ABSTRACT:

Background

Dysfunction of brain resting-state functional networks has been widely reported in sleep disorders, but their causal relationships remain controversial.

Objective

To investigate causal relationships between 191 resting-state functional magnetic resonance imaging (rsfMRI) phenotypes and eight sleep disorders using bidirectional two-sample Mendelian randomization (MR), with multivariable MR (MVMR) adjusting for addictive behaviors.

Methods

Genome-wide association study (GWAS) data from UK Biobank and FinnGen were analyzed. Instrumental variables (IVs) were selected adhering to MR assumptions. Causal estimates were primarily derived via inverse-variance weighted (IVW), with sensitivity analyses using MR-Egger, weighted median, weighted mode, simple mode, and M

SUBMITTER: Lin W 

PROVIDER: S-EPMC12504808 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature