Exosome-like nanovesicles from <i>Dunaliella salina</i> efficient sequential Co-delivery of anti-PDL1 and miR-375 for enhancing gene/immune therapy.

ABSTRACT:

Background

Esophageal cancer is one of the common malignant tumors of digestive system. Despite many advances in the treatment of esophageal cancer, many challenges remain. As an endogenous extracellular vesicle, exosomes are increasingly presenting their immense potential in drug delivery. However, it remains a bottleneck to obtain a large quantity of uniform, stable, and multi-component controllable exosomes with low cost and time.

Methods

A novel targeted drug delivery system based on exosome-like nanovesicles has been developed using the natural Marine single-celled salt Dunaliella salina (DENV) to conjugate c (RGDyK) peptide on its surface to achieve targeted drug delivery to esophageal cancer cells. In addition, miR-375 was loaded into cRGD-DENV by electroporati

SUBMITTER: Wei Z 

PROVIDER: S-EPMC12504820 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature