Investigating the Mechanism of Qifenggubiao Granules in COPD Treatment: An Integrated Exploration of Ferroptosis and the Gut-Lung Axis.

ABSTRACT: Although an increasing number of studies focus on treating chronic obstructive pulmonary disease (COPD) through the gut-lung axis and immunomodulation, its underlying mechanisms remain poorly understood. Previous research has shown that Qifenggubiao granules (QFGB) exhibit obvious clinical efficacy in treating allergic rhinitis and chronic cough, demonstrating excellent antioxidant and anti-inflammatory properties. However, whether it can alleviate COPD by inhibiting ferroptosis remains unclear. Additionally, its immunomodulatory mechanisms in gut microbiota dysbiosis-related inflammation require further investigation. In this study, we found that QFGB not only suppresses oxidative stress but also inhibits ferroptosis by reducing lipid peroxide levels and increasing the expression of gluta

SUBMITTER: Zheng M 

PROVIDER: S-EPMC12504822 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature