Pharmacogenetics of metamizole-induced agranulocytosis: a systematic review and drug regulation implications.

ABSTRACT:

Introduction

Metamizole (dipyrone) is a widely used analgesic and antipyretic, but its use has been restricted in some countries due to the risk of metamizole-induced agranulocytosis (MIA). This systematic review investigated genetic variants associated with MIA, allele frequencies across ancestry groups, and the drug's legal status.

Methods

A literature search was conducted across nine databases for studies published up to 08 April 2025. Study selection and data extraction were performed by two independent reviewers. The Withdrawn 2.0 platform was used to assess the global legal status of metamizole, while allele frequencies were obtained from the gnomAD browser (version v4.1.0) and the Allele Frequency Net Database (AFND). Bibliometric analysis was conducted using the VOS

SUBMITTER: Fidelis GFS 

PROVIDER: S-EPMC12504837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature