UVH6 regulates osmotic and heat stress tolerance by modulating transcription.

ABSTRACT: Nucleotide excision repair (NER) is a critical mechanism for repairing DNA damage, including UV-induced lesions and chemically induced adducts. The UVH6 gene encodes a subunit of the transcription factor IIH complex and is essential for both NER and transcription initiation. In Arabidopsis thaliana, UVH6 mutations impair DNA repair, enhance UV sensitivity, and decrease heat stress tolerance. We here isolated acquired osmotolerance-defective12 (aod12) mutant derived from osmotolerant Bu-5 accession; this mutant had pale green leaves and was osmosensitive and heat sensitive. Genetic and molecular analyses revealed that a mutation in UVH6 underlies these phenotypes of aod12. RNA sequencing demonstrated that UVH6 is necessary for appropri

SUBMITTER: Kobayashi K 

PROVIDER: S-EPMC12504840 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature