Remnant Cholesterol and Cardiovascular Risk in Adults With Type 1 Diabetes: A Nested Case-Control Study.

ABSTRACT:

Background

Despite advancements in therapeutic strategies, adults with type 1 diabetes (T1D) remain at high risk of cardiovascular disease (CVD). Traditional lipid parameters may not fully account for this residual risk. Remnant cholesterol-found in triglyceride-rich lipoproteins such as VLDL and IDL-has emerged as a potential contributor to atherogenesis but has not been extensively studied in T1D.

Methods

We conducted a nested case-control study within a multicentre Spanish cohort of 2187 adults with T1D. A total of 88 cases with a first CVD event (2010-2024) were matched 1:1 to controls by age, sex, diabetes duration, HbA1c, smoking, hypertension and retinopathy. Remnant cholesterol was calculated as total cholesterol minus HDL-C and LDL-C. Multivariable conditional logis

SUBMITTER: Sebastian-Valles F 

PROVIDER: S-EPMC12504852 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature