Chronic Kidney Disease Is a Risk Factor for the Development of Hyperchloremic Metabolic Acidosis After Repeated Therapeutic Plasma Exchanges.

ABSTRACT: Hyperchloremic metabolic acidosis is an underreported but common metabolic complication following therapeutic plasma exchange (TPE) with an albumin-saline solution, particularly when multiple TPE sessions are performed within a limited period. The risk of hyperchloremic metabolic acidosis may be the highest in patients with chronic kidney disease because of their limited acid excretion capacity. We prospectively collected data from all patients who received TPE at Amsterdam UMC between February 2023 and March 2025. We collected data on demographics, TPE-related parameters, and blood electrolyte concentrations. We investigated the effect of TPE on plasma sodium, chloride, and bicarbonate concentrations, the occurrence of adverse events, and the modulating role of kidney function. Data from

SUBMITTER: Simon SS 

PROVIDER: S-EPMC12504853 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature