High-Precision Hemodynamic and Echocardiographic Assessment of Pacing in Obstructive Hypertrophic Cardiomyopathy.

ABSTRACT:

Background

Left ventricular outflow obstruction drives symptoms and outcomes in obstructive hypertrophic cardiomyopathy (oHCM). Right ventricular pacing (RVP) can desynchronize the left ventricle to relieve this and allows control of atrioventricular delay (AVD) but may impair ventricular function. We used high-precision assessment to quantify the hemodynamic and echocardiographic effects of RVP in oHCM.

Methods

Patients with oHCM and implanted dual-chamber pacing devices underwent continuous recording of ECG, beat-by-beat outflow tract continuous wave Doppler, and beat-by-beat, noninvasive finger-cuff blood pressure while pacing was alternated between atrium-only pacing and AV-sequential RVP at a range of AVDs at 5 bpm above resting heart rate and 100 bpm. Changes in systol

SUBMITTER: Mohal JS 

PROVIDER: S-EPMC12504915 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature