Associations of prediagnostic serum liver enzyme levels with lung cancer risk in predominantly low-income African and European Americans.

ABSTRACT: Previous studies have linked liver diseases to lung cancer (LC) risk; however, few studies evaluated the associations of circulating liver enzyme levels with LC risk. We conducted a study of 353 incident LC cases and 646 matched controls with baseline serum alanine aminotransferase (ALT) and of 548 cases and 1032 matched controls with baseline serum alkaline phosphatase (ALP) nested within the Southern Community Cohort Study. Conditional logistic regression and generalized linear models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) among all study participants and by stratification of potential effect modifiers. Most participants had clinically normal liver enzyme levels. Higher serum ALT levels were associated with reduced LC risk. Compared with the l

SUBMITTER: Xu S 

PROVIDER: S-EPMC12504949 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature