Biohybrid Chlorella-HSA with Self-Oxygenation and Dual-Modal activation for synergistic Photo-Sonodynamic immunotherapy.

ABSTRACT: Multimodal dynamic therapies enhance precision oncology by synergistically harnessing reactive oxygen species (ROS)-mediated cytotoxicity, as exemplified in photodynamic and sonodynamic modalities. However, it faces key challenges including hypoxic tumors, low ROS yields, poor deep-tissue penetration, and immunosuppressive niches. To address these challenges, we engineered Chlorella vulgaris (Chl) into a biohybrid platform through sequential integration with 5,10,15,20-tetrakis(4-pyridyl)-21H,23H-porphine tetraiodide (TPP) and human serum albumin (HSA) (termed Chl@TPP/HSA) for synergistic photo-sonodynamic immunotherapy. This system integrates the photosynthetic oxygenation capacity of Chl with the dual photo-sonosensitizing properties of TPP, thereby overcoming hypoxia and amplifying cyto

SUBMITTER: Xu C 

PROVIDER: S-EPMC12504969 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature