Remote biofilm dislodgment using focused acoustic vortex.

ABSTRACT: Biofilms constitute a major challenge in treating implant-associated and chronic infections due to their structural resilience and drug resistance, particularly as implant demand rises due to aging populations. Conventional methods are often invasive, complex, and costly, while focused ultrasound (FUS) poses risks related to biocompatibility and tissue damage. Distinguished by its helical phase structure and rotational energy distribution, focused acoustic vortex (FAV) theoretically generates stronger rotational forces and acoustic streaming than FUS under identical acoustic conditions. This study investigates the feasibility of FAV technique for biofilm removal. Biofilms in vitro model were established using Escherichia coli, and a 2-MHz custom-built ultrasound transducer was employed to

SUBMITTER: Li CH 

PROVIDER: S-EPMC12504976 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature