Design and synthesis of macrocycles with tuneable diameters and helical foldamers with customizable peripheral side chains.

ABSTRACT: Tubular structures with nanosized pores have shown remarkable applications in areas such as ion transport and water filtration, but their development is often hindered by challenges including low yields, limited functionalization, and poor uniformity. Herein, we present a new series of macrocycles with tuneable diameters and helical foldamers featuring customizable peripheral side chains. The macrocycles, with diameters ranging from 0.8 to 1.4 nm, were synthesized in moderate to good yields using a one-pot method. Solid-state analysis revealed that these macrocycles form nanochannels, highlighting their potential applications in areas such as molecular recognition and artificial water channels (AWCs). Additionally, we synthesized helical aromatic amide polymers with narrow dispersities

SUBMITTER: Farooq S 

PROVIDER: S-EPMC12504988 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature