Assessing the mechanism of osteosarcoma induced by long-term PET exposure: prediction from combined network toxicology, machine learning and molecular docking.

ABSTRACT:

Objective

Polyethylene terephthalate (PET) has emerged as a focal point in addressing global pollution and a critical environmental issue due to its potential health hazards. However, its role in the pathogenesis of osteosarcoma (OS) and the underlying molecular mechanisms remain largely unexplored, further highlighting the necessity of assessing its molecular toxicity.

Methods

This study integrated network toxicology, machine learning, molecular docking, and CIBERSORT-based immune infiltration analysis to systematically investigate the potential impact of PET exposure on contracting OS, elucidating its biological functions, signaling mechanisms, and immune microenvironment. Molecular docking was further applied to characterize the binding properties of PET with hub proteins

SUBMITTER: Qiao Y 

PROVIDER: S-EPMC12505009 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature