Sex differences in vulnerability to tau pathology: Impact on cognitive decline.

ABSTRACT:

Introduction

Although the link between the presence of amyloid and tau pathologies, neurodegeneration, and cognitive decline in aging individuals is established, it is less clear whether there are sex differences in vulnerability to these pathologies.

Methods

A total of 1464 participants (7168 longitudinal assessments, 4.77 ± 3.78 years of follow-up) were included from the National Alzheimer's Coordinating Center (NACC) database. Longitudinal mixed effects and mediation models examined the sex differences across cognitive decline trajectories of amyloid (A), tau (T), and neurodegeneration (N) groups.

Results

A⁺T^- males showed faster cognitive decline compared to A⁺T^- females (p < 0.005), whereas A⁺T⁺ fe

SUBMITTER: Zeighami Y 

PROVIDER: S-EPMC12505017 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature