Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase-derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance.

ABSTRACT:

Introduction

Type 2 diabetes mellitus (T2DM) is a risk factor for dementia and cerebral small vessel disease, but there remains a need to identify targetable molecular pathways involved in the underlying pathophysiology.

Methods

In participants with Alzheimer's disease, related dementias, or cerebrovascular diseases, we assessed associations between ratios of unesterified linoleic acid (LA)-derived soluble epoxide hydrolase (sEH) metabolites (diols) and substrates (epoxides), with imaging-derived white matter hyperintensities (WMHs), brain parenchymal fraction (BPF), and cognitive performance. Potential moderation effects by glycemic control (hemoglobin A1c [HbA1c]) were examined.

Results

With elevated HbA1c, greater LA-derived diol/epoxide ratios were associated with

SUBMITTER: Ryoo SW 

PROVIDER: S-EPMC12505018 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature