Variability of longitudinal sleep monitoring in amyloid-negative and amyloid-positive cognitively unimpaired and mildly impaired older adults.

ABSTRACT:

Introduction

Sleep disturbances are associated with Alzheimer's disease (AD) pathology and cognitive symptoms, but few studies have longitudinally assessed sleep, AD biomarkers, and cognition. Understanding how sleep changes over time in older adults with and without AD pathology is crucial for appropriately designing longitudinal studies of aging and AD.

Methods

Sleep was measured over ≈3.5 years in older adults using self-reported questionnaires and an at-home single-channel electroencephalography (scEEG) device. Participants also underwent amyloid imaging and cognitive testing. Longitudinal change of multiple sleep parameters was determined and sample sizes estimated for future clinical trials using sleep as an outcome.

Results

In both amyloid groups, EEG spectral

SUBMITTER: Pedersen TJ 

PROVIDER: S-EPMC12505026 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature