Lung development genes, adult lung function and cardiovascular comorbidities.

ABSTRACT:

Background

The association between lower adult lung function and increased cardiovascular comorbidity has not been adequately explained. We investigated whether shared developmental signalling pathways, critical to lung development and repair, could partly explain it.

Methods

In UK Biobank (UKB), we performed pairwise colocalisation analysis of variants in 55 lung development genes associated with adult forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV₁)/FVC, to see if these are also associated with coronary heart disease (CHD), blood pressure (systolic, diastolic, hypertension), pulse pressure, Arterial Stiffness index and carotid intima-media thickness. For CHD, we meta-analysed data from UKB and the CARDIoGRAM consortium.

Results

We fou

SUBMITTER: Portas L 

PROVIDER: S-EPMC12505039 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature