Photoreceptor cone loss is associated with decreased deep retinal vessel density and impaired retinal sensitivity in high myopia.

ABSTRACT:

Purpose

To assess alterations in cone morphology, retinal sublayer thicknesses and vessel densities (VDs) in eyes with non-pathological high myopia (HM) and their correlation with retinal sensitivity (RS).

Methods

This prospective study included 43 patients with non-pathological HM and 38 age-matched healthy volunteers. Participants underwent detailed ophthalmic evaluations. Cone morphology was assessed using adaptive optics scanning laser ophthalmoscopy. The thicknesses of the myoid and ellipsoid zone (MEZ), photoreceptors outer segment (OS), central macula and choroid were measured by optical coherence tomography (OCT). Retinal VDs of the superficial and deep capillary plexus (DCP) were evaluated by OCT angiography, and RS was assessed through microperimetry. Group compari

SUBMITTER: Liang J 

PROVIDER: S-EPMC12505059 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature