Toxic microbiome and progression of chronic kidney disease: insights from a longitudinal CKD-Microbiome Study.

ABSTRACT:

Background

The gut microbiota has been linked to non-communicable diseases, including chronic kidney disease (CKD). However, the relationships between gut microbiome composition changes, uraemic toxins (UTs) accumulation, and diet on CKD severity and progression remain underexplored.

Objective

To characterise relationships between gut microbiome composition and functionality, UTs diet, and CKD severity and progression, as well as assess microbial contributions to UTs accumulation through mice faecal microbiota transplantation (FMT).

Design

This study profiled the gut microbiome of 240 non-dialysis patients with CKD (CKD-REIN cohort) using shotgun metagenomics, with follow-up in 103 patients after 3 years, with comparisons with healthy volunteers from the Milieu Int

SUBMITTER: Laiola M 

PROVIDER: S-EPMC12505076 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature