Factors associated with outcomes following autologous haematopoietic stem cell transplantation for multiple sclerosis.

ABSTRACT:

Background

Autologous haematopoietic stem cell transplantation (AHSCT) has emerged as a highly effective treatment for relapsing-remitting multiple sclerosis (RRMS), though patient selection remains challenging. The degree to which disease-modifying therapies (DMTs) and procedure-related complications affect treatment outcomes is unclear. The objective of this study was to investigate the factors that might influence outcomes following AHSCT.

Methods

Data from the multicentre, retrospective cohort study Haematopoietic Stem Cell Transplantation for Treatment of Multiple Sclerosis in Sweden (AutoMS-Swe) were analysed, comprising 174 patients with RRMS who received AHSCT before 1 January 2020. Primary outcomes included inflammatory disease activity, confirmed disability worseni

SUBMITTER: Noui Y 

PROVIDER: S-EPMC12505080 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature