Role of complete blood count in the diagnosis of culture-proven neonatal sepsis: a systematic review and meta-analysis.

ABSTRACT:

Objective

Neonatal sepsis is a significant cause of morbidity and mortality, particularly in preterm infants. Despite its routine use in adults, the diagnostic utility of complete blood count (CBC) in neonatal sepsis remains debated. This systematic review and meta-analysis aimed to evaluate the diagnostic accuracy of CBC parameters for neonatal sepsis.

Methods

This review was registered at PROSPERO (CRD42023476510). MEDLINE, Embase, CINAHL and the Cochrane Library were searched from database inception to 28 October 2024. Observational studies of neonates with sepsis, published in English, were included. Pooled diagnostic accuracy metrics were calculated for CBC parameters, including the white cell count (WCC), neutrophil count and immature-to-total neutrophil ratio (ITR). B

SUBMITTER: Hyde E 

PROVIDER: S-EPMC12505116 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature