Genetic and Multi-Omics Insights Into Monocyte Pantothenate-Mediated Protection in Acute Respiratory Distress Syndrome.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is a severe condition with complex pathogenesis, and emerging evidence highlights the potential role of metabolic factors, though the exact mechanisms are not fully understood. In this study, we used Mendelian randomisation (MR) and multi-omics approaches to investigate the causal relationship between plasma metabolites, immune cell profiles and ARDS risk. MR analysis of 1400 metabolites identified two causal metabolites linked to increased ARDS risk, primarily involved in pantothenate and CoA biosynthesis. Single-cell RNA sequencing of ARDS samples revealed that monocytes exhibited the highest levels of pantothenate synthesis. Intercellular communication and pseudotime analysis suggested that the pantothenate synthesis pathway influenced monocyte

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12505201 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature