Sorbitol-Induced Synchronisation of Babesia duncani and Assessment of Linoleic Acid Effect on Parasite-Derived Vesicles.

ABSTRACT: Human babesiosis is an emerging infectious disease caused by a bloodborne single-celled parasite belonging to the genus Babesia. Cases of human babesiosis are commonly reported in the United States, Western Europe and Asia. In the United States, the two major causative agents are Babesia microti and Babesia duncani. Transmitted to humans through tick bites, the parasite infects host red blood cells (RBCs). It induces flu-like symptoms and has evolved mechanisms to manipulate the immune system, enabling its persistence. One key mechanism is the secretion of extracellular vesicles (EVs) which carry bioactive molecules, including proteins, lipids and genetic material that modulate pathogen-host interactions and disease development. The inhibition of the secretion of these vesicles may lead to

SUBMITTER: Haak S 

PROVIDER: S-EPMC12505203 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature