A Comparative Study of Flash Nanoprecipitation and Sequential Nanoprecipitation: Impact of Formulation Parameters on Drug-Loaded Nanoparticle Formation.

ABSTRACT: Flash NanoPrecipitation (FNP) is a well-established method for forming core-shell drug-loaded nanoparticles that has demonstrated effectiveness for encapsulating highly hydrophobic compounds. However, certain formulation challenges persist, including size limitations and reduced encapsulation efficiency for moderately hydrophobic drugs. Sequential NanoPrecipitation (SNaP) is a novel nanoparticle synthesis process that relies on the same assembly principle as FNP, while decoupling the core formation and stabilization. Through a systematic comparison using drugs with varying hydrophobicity, we demonstrate complementary capabilities between these techniques. We showed that for the high hydrophobicity drugs such as β-carotene, both SNaP and FNP performed effectively. In the case of cinnarizine

SUBMITTER: El Amri N 

PROVIDER: S-EPMC12505255 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature