Probing the Influence of Water on the Molecular Mobility of PVP/VA using Terahertz Spectroscopy.

ABSTRACT: The presence of water significantly impacts the physical stability of amorphous solid dispersions (ASDs) by altering polymer molecular mobility. This study investigates the influence of low levels of absorbed water on the molecular dynamics and glass transition behavior of amorphous poly(vinylpyrrolidone-co-vinyl acetate) (PVP/VA). Melt-quenched PVP/VA discs were conditioned at controlled relative humidities (RH 8.5 to 75%) and characterized using variable-temperature terahertz time-domain spectroscopy (THz-TDS, 80 to 420 K) and differential scanning calorimetry (DSC). DSC confirmed a significant plasticizing effect, with the glass transition temperature (T_g) decreasing from 367 to 275 K with increasing hydration. THz-TDS absorption correlated linearly with water c

SUBMITTER: Santitewagun S 

PROVIDER: S-EPMC12505260 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature