3D Bioprinting and Artificial Intelligence for Tumor Microenvironment Modeling: A Scoping Review of Models, Methods, and Integration Pathways.

ABSTRACT: Recent advances in cancer research emphasize the development of physiologically relevant models to better understand tumor behavior and therapeutic responses. The tumor microenvironment (TME) plays a pivotal role in tumor progression, metastasis, and treatment resistance. Three-dimensional (3D) bioprinting offers unique capabilities for constructing complex in vitro tumor models that closely replicate the TME heterogeneity and interactions. These biomimetic models surpass the limitations of traditional 2D cultures and reduce the reliance on animal testing. This review aimed to systematically map current research on 3D bioprinting and artificial intelligence (AI) applications in modeling TME across selected cancer types. The review was structured into three thematic domains: 3D bioprinting

SUBMITTER: Piotrowska U 

PROVIDER: S-EPMC12505267 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature