Trade-off between antibacterial immune defense and oogenesis progression in female Drosophila melanogaster.

ABSTRACT: Trade-offs between reproduction and immunity are common in animals, potentially due to preferential allocation of limiting resources. In Drosophila melanogaster, mating stimulates egg production but also triggers a rapid and persistent decrease in female immune defense. Proteins essential for both processes are produced in fat body tissue, which may result in competition for cellular resources that could drive a functional trade-off between reproduction and immune defense. We predicted that arrest of oogenesis prior to egg provisioning would alleviate postmating immune suppression because cellular stress would be relieved, but that postmating immune suppression would be observed in genotypes that fully provision eggs even if fertility is compromised. In the present study, we test these pre

SUBMITTER: Gordon KE 

PROVIDER: S-EPMC12505294 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature