Multiple autism genes influence GABA neuron remodeling via distinct developmental trajectories.

ABSTRACT: Variation in over 100 genes is now associated with increased risk for autism and related neurodevelopmental conditions, but how this variation results in distinct and overlapping behavioral changes is still not well understood. Recent efforts have focused on screening many autism genes at once for functional and phenotypic convergence, and identified subsets that are crucial for many early steps of neurodevelopment. Few studies have screened later steps of neurodevelopment, circuit function, circuit plasticity, or behaviors. We screened 20 conserved autism-associated genes for impact on experience-dependent neuron remodeling in Caenorhabditis elegans. Loss of unc-44/ANK2, set-4/KMT5B, daf-18/PTEN, gap-2/SYNGAP1, and chd-1/CHD2/8 increased, while unc-36/CACNA2D3 decreased, neurite outgrowth

SUBMITTER: Zoga K 

PROVIDER: S-EPMC12505306 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature