Differential Modulation of Skin Barrier Proteins and Lipid Synthesis by <i>Staphylococcus aureus</i>, <i>Staphylococcus hominis</i>, and <i>Cutibacterium acnes</i>.

ABSTRACT:

Background

The skin microbiome plays a critical role in regulating epidermal differentiation and immune responses. Understanding of how individual microbial species influence the expression of barrier proteins and lipid synthesis pathways is essential for elucidating their contributions to skin barrier function.

Objective

This study aimed to investigate the distinct effects of Staphylococcus aureus (S. aureus), Staphylococcus hominis (S. hominis), and Cutibacterium acnes (C. acnes) on the skin barrier protein expression and lipid synthesis, thereby clarifying their roles in maintaining skin barrier integrity and homeostasis.

Methods

Keratinocyte 2-dimensional monolayer cultures and self-assembled 3-dimensional skin models were

SUBMITTER: Kim H 

PROVIDER: S-EPMC12505365 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature