Approaching the physical limits of specific absorption rate for synthetic antiferromagnetic nanodisks in hyperthermia applications.

ABSTRACT: Magnetic nanoparticle-based hyperthermia presents a promising approach to treating malignant solid tumors that are resistant to conventional therapies such as chemotherapy and radiation. However, the therapeutic potential of superparamagnetic iron oxide nanoparticles (SPIONs) is limited by low saturation magnetization, superparamagnetic behavior, and broad particle size distribution. Here, we present synthetic antiferromagnetic disk particles (SAF-MDPs) designed through micromagnetic modeling to maximize hysteretic heating while maintaining suspension stability. The SAF-MDPs feature in-plane magnetization optimized via uniaxial anisotropy adjustments to prevent spin-flop phenomena and eliminate hysteresis-free loops along the hard axis. Mechanofluidic modeling was used to assess par

SUBMITTER: Scheibler S 

PROVIDER: S-EPMC12505462 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature