Antifungal mechanism of ketone volatile organic compounds against <i>Pseudogymnoascus destructans</i>.

ABSTRACT: Ketone volatile organic compounds have demonstrated favorable inhibitory activity against a wide range of pathogenic fungi, including Pseudogymnoascus destructans (Pd), the lethal pathogenic fungus responsible for white-nose syndrome in bats. However, the mechanism of fungal inhibition by ketones remains unclear. In this study, we employed transcriptomic analysis to conduct RNA sequencing on Pd treated with 2-undecanone and 2-nonanone, aiming to investigate the effects of these ketones on the gene expression profiles of Pd. The results indicated that 2-undecanone and 2-nonanone inhibit spore germination in Pd and cause significant damage to its mycelium. The minimum inhibitory concentrations (MIC) were determined to be 25.94 μg/mL and 135.41 μg/mL, respec

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12505510 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature