Genetic diversity and natural selection of circumsporozoite surface protein in Vietnam Plasmodium falciparum isolates.

ABSTRACT:

Background

Plasmodium falciparum circumsporozoite surface protein (PfCSP) serves as a prime candidate for malaria vaccine; however, its substantial genetic diversity presents significant challenges in development of universal vaccines. This study investigated the genetic diversity and natural selection of the pfcsp in P. falciparum isolates from Vietnam. Comparative analysis of 836 global pfcsp sequences from different geographical regions was also performed.

Methods

Blood samples were obtained from individuals infected with P. falciparum in five malaria-endemic provinces in Central Vietnam from 2018 to 2022. The pfcsp gene was amplified, cloned, and sequenced, yielding 95 pfcsp sequences. Nucleotide diversity and natural selection of pfcsp were analysed by programs, such as

SUBMITTER: Vo TC 

PROVIDER: S-EPMC12505560 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature