Elevated VAMP8 expression promotes cervical cancer progression by enhancing autophagy via HIF-1 pathway.

ABSTRACT:

Background

Cervical cancer, prevalent in low- and middle-income countries, is primarily caused by high-risk HPV16. Vesicle-Associated Membrane Protein 8 (VAMP8), involved in vesicle trafficking and autophagy, may influence HPV16-related cervical cancer progression.

Methods

VAMP8 expression was evaluated in cervical tissue specimens from patients with HPV16-positive lesions (including low- and high-grade squamous intraepithelial lesions and cancer) and HPV-negative normal controls using proteomics, qPCR, and immunohistochemistry. A Cox proportional hazards model for prognosis was developed using immunohistochemical data from a cohort of cervical cancer patients. The clinical significance of VAMP8 was further assessed using RNA-seq and clinical data from The Cancer Genome Atla

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12505561 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature