Ten mouse organs proteome and metabolome atlas from adult to aging.

ABSTRACT:

Background

Aging is a complex biological process characterized by progressive molecular alterations across multiple organ systems, significantly influencing disease susceptibility and mortality. Unraveling molecular interactions driving aging is crucial for interventions promoting healthy aging and mitigating senescence. However, the systemic mechanisms governing both inter-organ interactions and organ-specific aging trajectories remain incompletely characterized.

Methods

To investigate the molecular dynamics of aging, we conducted a systematic multi-omics analysis of 400 tissue samples collected from 10 organs (brain, heart, intestine, kidney, liver, lung, muscle, skin, spleen, and stomach) in mice at four distinct life stages: 4, 8, 12, and 20 months (from youth to elderly

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12505602 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature