Multigenerational temperature effects on paternal epigenetic inheritance in European sea bass.

ABSTRACT: Environmental changes can induce epigenetic modifications, influencing gene expression, phenotype, and species adaptation. This study investigates how temperature affects genome-wide DNA methylation patterns, particularly in genes crucial for sex development and whether these modifications can be transmitted across generations. Using the European sea bass -a fish model with both genetic and environmental sex determination- we analyzed DNA methylation at single nucleotide resolution using reduced representation bisulfite sequencing in 64 individuals from five families across two generations (F0 and F1). Parental fish (F0) were exposed to either control (16 °C, C) or elevated (21 °C, T) temperatures from 12 to 60 days post-fertilization. Their offspring (F1) were then subjected to four therm

SUBMITTER: Sanchez-Baizan N 

PROVIDER: S-EPMC12505611 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature