STARSHIP Part 2: Disturbed Pressure Reactivity Duration and Magnitude in Pediatric Severe Traumatic Brain Injury-Outcome Implications.

ABSTRACT: Cerebral autoregulation (CA) plays a critical role in maintaining cerebral blood flow (CBF) amid fluctuations in systemic blood pressure, with dysfunction increasing vulnerability to secondary brain injury, particularly after traumatic brain injury (TBI). While extensively studied in adults, CA dynamics in pediatric TBI (pTBI) remain relatively unexplored. Studying Trends in AutoRegulation in Severe Head Injury in Pediatrics (STARSHIP), the first multicenter, prospective study on CA in pTBI, investigates the pressure reactivity index (PRx) and its association with outcomes. PRx, calculated as the Pearson's correlation between mean arterial pressure and intracranial pressure, provides insights into the patient's CA status. In this article, STARSHIP Part 2 characterizes PRx disturbances usin

SUBMITTER: Smith CA 

PROVIDER: S-EPMC12505629 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature