Pomegranate root extract possesses anti-metastatic potential by suppressing invasiveness and vasculogenic mimicry capability of cancer cells.

ABSTRACT: Cancer metastasis is a serious problem in cancer treatment. Metastasis is driven by cancer invasiveness and facilitated by angiogenesis of endothelial cells. Collective evidence revealed that highly invasive cancer cells possess vasculogenic mimicry (VM) capability by forming non-endothelial capillaries that mimic blood vessels. Moreover, VM also resists anti-angiogenic drugs. Thus, anti-invasion and anti-VM are necessary approaches required for anti-metastasis therapy. Pomegranate plants (Punica granatum L.) have been used in traditional medicines since ancient times. Different parts of the pomegranate tree possess the ability to inhibit cancer cell invasion and migration, but there is no report for pomegranate roots. This study aimed to explore anti-metastatic and anti</

SUBMITTER: Chiablaem K 

PROVIDER: S-EPMC12505693 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature