WGX50 attenuates radiation enteritis by targeting ferroptosis and redox homeostasis via EGFR.

ABSTRACT:

Background

Radiation enteritis (RE) is a common complication in patients undergoing abdominal and pelvic radiotherapy. Despite the advancements in radiotherapy, effective treatments remain limited. WGX50, a bioactive compound from Sichuan pepper, has shown anti-inflammatory and antioxidant properties. This study investigates the protective effects of WGX50 on RE, focusing on its potential to reduce radiation-induced damage in the intestine.

Methods

Network pharmacology and molecular docking were used to identify the molecular targets of WGX50. In vitro, human intestinal epithelial cells (HIEC6) and colon cells (NCM460) were exposed to radiation and treated with WGX50. In vivo, C57BL/6 mice were administered WGX50 prior to radiation exposure. Various assays, including CCK-8,

SUBMITTER: Yin Z 

PROVIDER: S-EPMC12505694 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature