The pathobiont role of Akkermansia muciniphila in colorectal cancer: a systematic review.

ABSTRACT:

Background

Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. Emerging evidence highlights the gut microbiota, particularly Akkermansia muciniphila, as a key modulator in CRC pathogenesis. While often regarded as a beneficial commensal, its role in CRC appears complex and potentially dualistic.

Objective

This systematic review aims to comprehensively analyze the context-dependent role of A. muciniphila in CRC, evaluating its potential as a pathobiont.

Methods

We systematically reviewed human, animal, in vitro, and ex vivo studies on associations between A. muciniphila and CRC risk or outcomes. Database searches identified 34 eligible studies. Study quality was assessed using the GRADE criteria.

Results

From 244 initial re

SUBMITTER: Soheilipour M 

PROVIDER: S-EPMC12505710 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature