Association of CYP3A5 rs15524 and CYP3A7 rs776744 polymorphisms on tac IPV and clinical outcomes in early post-heart transplantation.

ABSTRACT:

Background

The intrapatient variability (IPV) of tacrolimus (Tac) has gradually become a new index for the prognosis of organ transplantation. The gene polymorphism is involved in the pharmacokinetic process of Tac. The aim of this study was to investigate the effects of genetic polymorphisms on Tac IPV and other clinical outcomes in heart transplant recipients during the early post-transplantation period.

Methods

Our study retrospectively collected the clinical data and genotyping results of 48 heart transplant recipients. SPSS (21.0) and Graphpad Prism (8.0) were used to analyze the effect of gene polymorphism on Tac concentration (C₀) and clinical outcome.

Results

The CYP3A5 rs15524 AA genotype has a higher trough concentrations/dose (C₀/D) va

SUBMITTER: Chai Y 

PROVIDER: S-EPMC12505756 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature