Comparative genomic analysis of Mycoplasma pneumoniae isolated in the United Kingdom, between 2016 and 2024.

ABSTRACT:

Background

Mycoplasma pneumoniae is a bacterium that causes upper and lower respiratory infections in children and adults. Epidemics occur over the winter period every few years with the most recent seen in 2023/24. These epidemics are thought to be due to the circulation of p1 type variants of M. pneumoniae which have cyclic epidemiology, with the peaks of infection driven by naïve individuals, mainly those < 5-years-old. Currently there is no routine monitoring or genomic surveillance to detect variants of M. pneumoniae circulating in the UK. We analysed 38 genomes of M. pneumoniae isolated in the UK between 2016 and 2024 for the detection of Macrolide-resistant M. pneumoniae (MRMP) and typing of M. pneumoniae variants. Core-genome analysis was used to compare the M. pneumoniae U

SUBMITTER: Tewolde R 

PROVIDER: S-EPMC12505857 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature