Antibiotic resistance profiles of seven genomospecies of <i>Corynebacterium jeikeium</i> analyzed by whole genome sequencing.

ABSTRACT: Corynebacterium jeikeium is an opportunistic human pathogen with high genomic diversity. In the past, multi-drug resistance has been considered a hallmark of C. jeikeium. However, some strains of C. jeikeium are fully susceptible and thus, their reclassification would avoid the empirical therapy with glycopeptides. One hundred eighty-six clinical isolates and four reference isolates identified as C. jeikeium between 1994-1999 and 2012-2019, respectively, were analyzed by matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) and 16S ribosomal RNA (16S rRNA) gene sequence analysis. A total of 153 confirmed C. jeikeium isolates was further analyzed by whole genome sequencing (WGS) and by disk diffusion antimicrobial susc

SUBMITTER: Fischer-Wellenborn M 

PROVIDER: S-EPMC12505879 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature