Inhibitory activities of monoclonal antibodies against <i>Staphylococcus aureus</i> clumping factor A.

ABSTRACT: Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease associated with high mortality and without specific intervention. Clumping factor A (ClfA) displayed on the bacterial surface plays a key role in promoting S. aureus replication during invasive disease. Decades of research have pointed to a wide array of ligands engaged by ClfA. The sum of these interactions supports the unique ability of this pathogen to survive and replicate in the blood stream. One such ligand is fibrin. ClfA acts as the key agglutinating factor of S. aureus by promoting the shielding of bacteria in fibrin cables and their physical escape from phagocytes. Here, we compare a series of monoclonal antibodies elicited against the ligand binding domain of ClfA following im

SUBMITTER: Banerjee B 

PROVIDER: S-EPMC12505888 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature