Host-encoded ETP2 is involved in recruiting the dynamin-like protein ETP9 to the endosymbiont division site in trypanosomatid <i>Angomonas deanei</i>.

ABSTRACT: A single β-proteobacterial endosymbiont, Candidatus Kinetoplastibacterium crithidii, resides in the cytosol of the trypanosomatid Angomonas deanei and divides at a defined stage of its host's cell cycle. This endosymbiont has a highly reduced genome of 0.8 Mb and, notably, has lost most essential bacterial division genes, resulting in a loss of division autonomy. It has been previously demonstrated that a host-encoded dynamin-like protein, endosymbiont-targeted host protein (ETP)9, plays an indispensable role in the division of the endosymbiont. In this study, we identified a second nucleus-encoded component of the endosymbiont division machinery, termed ETP2, currently annotated as a "hypothetical protein." We observed that ETP2 arrives before ETP9 at th

SUBMITTER: Maurya AK 

PROVIDER: S-EPMC12505957 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature