Small pangenome of <i>Candida parapsilosis</i> reflects overall low intraspecific diversity.

ABSTRACT: Candida parapsilosis is an opportunistic yeast pathogen that can cause life-threatening infections in immunocompromised humans. Whole-genome sequencing studies of the species have demonstrated remarkably low diversity, with strains typically differing by about 1.5 single nucleotide polymorphisms (SNPs) per 10 kb. However, SNP calling alone does not capture the full extent of genetic variation. Here, we define the pangenome of 372 C. parapsilosis isolates to determine variation in gene content. The pangenome consists of 5,859 genes, of which 48 are not found in the genome of the reference strain. This includes 5,791 core genes (present in ≥99.5% of isolates). Four genes, including the allantoin permease gene DAL4, were present in all isolates but were truncated i

SUBMITTER: Ryan AP 

PROVIDER: S-EPMC12505961 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature